Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression

Breast cancer is one of the most lethal malignancies in women worldwide and characterized by rapid growth low survival rates, despite advances tumor biology therapies. Novel therapeutic approaches require new insights into molecular mechanisms malignant transformation progression. To this end, here, we identified Prox1 as a negative regulator proliferation tumor-related metabolism breast cancer. In particular, showed that tumors from human patients exhibited reduced levels expression, while high expression were associated with favorable prognosis patients. Moreover, experimentally demonstrated was sufficient to strongly suppress proliferation, migration, Warburg effect cells without inducing apoptosis. Most importantly, over-expression inhibited vivo both heterotopic orthotopic xenograft mouse models. The anti-tumorigenic mediated direct repression c-Myc transcription its downstream target genes. Consistently, an artificial promoter not targeted reversed Prox1’s anti-tumor effects. These findings suggest has suppressive role via transcriptional regulation c-Myc, making it promising gene for